MEDICATIONS THAT AFFECT THE IMMUNE SYSTEM. VITAMINS

Abstract

In order to treat illness and reduce undesirable side effects, it is important to understand how medications impact the immune system (IS). Here, we introduce an integrative computational method for system-wide drug-immune cell  (IC) interaction prediction. The method compares gene sets across transcriptional profiles to ascertain how similar they are. We use the approach to anticipate 69,995 known and novel interactions by modeling the interactions between 1,309 medicines and 221 IC types. Five medicines' effects on four IC types in people and mice are predicted using the generated IC pharmacology map. We looked at cell population changes from in vivo experiments and patient records to confirm the predictions. Our approach provides a tool for identifying drug connections by screening thousands of interactions. It has long been understood that food components are
essential to the human body's growth and development because they provide defensive functions against outside substances that can pose serious health risks to the general public. The human body needs micronutrients, like vitamins and minerals, and people must get enough of these each day from their food. By protecting the human immune response and acting as immunomodulators, micronutrients stop harmful organisms from evading the immune system. To evaluate the immunomodulatory effects of vitamins and minerals, a number of experimental studies have been conducted. This review outlines the immuneboosting properties of micronutrients and the mechanisms of action that mediate these properties in light of these experimental findings. Vitamin and mineral deficiencies in plasma concentrations can result in a decrease in immune system function and are a major cause of adverse immunological conditions. The features of the immune system and the use of micronutrients (vitamins and minerals) in preventative measures intended to lower morbidity and mortality among patients
with autoimmune diseases or immunological invasions are described in this review.